With the introduction of prostate-specific antigen (PSA) testing, the number of PCa diagnoses has increased, but the rate of dying from PCa has decreased [6-10]. Although a routine test, PSA screening has garnered a lot of criticism over the years due to the possibility of over detection, which leads to over treatment [11-14].
Offer a digital rectal examination (DRE). DRE allows assessment of the prostate for signs of prostate cancer (a hard gland, sometimes with palpable nodules) or benign enlargement (smooth, firm, enlarged gland). Note that a gland that feels normal does not exclude a tumour. Consider prostate-specific antigen (PSA) testing. The European Randomized Study of Screening for Prostate Cancer (ERSPC) showed that prostate-specific antigen (PSA) screening significantly reduced prostate cancer mortality (rate ratio (RR)=0.79, 95%CI 0.69-0.91). The U.S. Prostate, Lung, Colorectal, and Ovarian (PLCO) trial showed no such reduction but had a wide confidence interval (RR for
Prostate multiparametric MRI (mpMRI) has been examined as an adjunct test to PSA to better identify patients who require a prostate biopsy for the presence of aggressive forms of prostate cancer.3 Randomised clinical trials have shown that mpMRI can improve the predictive value for the presence of clinically significant prostate cancer
RT-PCR is extremely sensitivity in detecting tissue-specific mRNA of tumor markers such, as PSA ( 45 ), hK2 ( 46 ), and more recently, prostate-specific membrane antigen (PSMA). PSMA is a 100-kDa transmembrane glycoprotein identified in all types of prostatic tissue, but particularly elevated in carcinomas.
The Canadian Urological Association recommends screening with both DRE and PSA in all average-risk men aged 50 years and older with a minimum life expectancy of 10 years. 7 In contrast, the Canadian Task Force on Preventive Health Care recommends against use of the PSA test for prostate cancer screening in men aged 55 years or older without a

Prostate cancer remains the most common cancer in men. Qualitative or semi-quantitative immunochromatographic measurements of prostate specific antigen (PSA) have been shown to be simple, noninvasive and feasible. The aim of this study was to evaluate an optimized gold immunochromatographic strip device for the detection of PSA, in which the results can be analysed using a Chromogenic Rapid

PSA testing has increased the number of men diagnosed with and treated for prostate cancer, but many of these men would never have experienced any symptoms or death from prostate cancer This guideline makes a weak recommendation against offering systematic PSA screening based on an updated systematic review.
Prostate-Specific Antigen (PSA) is a first-line recommended serum biomarker used for prostate cancer (PCa) screening. However, this test has critical limitations in specificity within the gray eyssmU.
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    • sensitivity of psa test for prostate cancer